c-Src expression in the limbic system and the Wnt/β-catenin pathway in a kindling model of epilepsy in calorie-restricted rats

Poster

Contact

• NameOmar Villa-Robledo, MD
• Institutional emailvilla.omar@uabc.edu.mx
• Emailcontact@villarobledo.me
• ORCIDiD0009-0006-8968-9837

References

1. World Health Organization. Epilepsy [fact sheet]. who.int/news-room/fact-sheets/detail/epilepsy
2. Xue-Ping W, Hai-Jiao W, Li-Na Z, Xu D, Ling L. Risk factors for drug-resistant epilepsy: a systematic review and meta-analysis. Medicine (Baltimore). 2019;98(30):e16402. doi:10.1097/MD.0000000000016402
3. Blümcke I, Thom M, Aronica E, et al. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013;54(7):1315–1329. doi:10.1111/epi.12220
4. Bough KJ, Schwartzkroin PA, Rho JM. Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia. 2003;44(6):752–760. doi:10.1046/j.1528-1157.2003.55502.x
5. Phillips-Farfán BV, Rubio Osornio MC, Custodio Ramírez V, Paz Tres C, Carvajal Aguilera KG. Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway. Front Cell Neurosci. 2015;9:90. doi:10.3389/fncel.2015.00090
6. Rubio C, Luna R, Rosiles A, Rubio-Osornio M. Caloric restriction and ketogenic diet therapy for epilepsy: a molecular approach involving Wnt pathway and K_ATP channels. Front Neurol. 2020;11:584298. doi:10.3389/fneur.2020.584298
7. Yadav N, Priya, Dixit N, Anand S, Banerjee J, Tripathi M, et al. Altered fibronectin-α5β1 integrin-Src signalling pathway drives network hyperexcitability in the hippocampal formation and anterior temporal lobe in temporal lobe epilepsy. Neurochem Res. 2026;51(1):32. doi:10.1007/s11064-025-04656-9
8. Roura S, Miravet S, Piedra J, García de Herreros A, Duñach M. Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J Biol Chem. 1999;274(51):36734–36740. doi:10.1074/jbc.274.51.36734

Affiliations

• Laboratory of Neurophysiology, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Mexico City
• Facultad de Medicina y Nutrición, Universidad Autónoma de Baja California, Mexicali
• Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Iztapalapa
• Facultad Mexicana de Medicina, Universidad La Salle México
• Department of Neurochemistry, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Mexico City

About me

I am a Mexican physician (MD, Universidad Autónoma de Baja California) doing a research placement in the Laboratory of Neurophysiology at the Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez” in Mexico City.

I am pursuing a General Surgery residency in the United States and aim to build a career as a surgeon-scientist. I am also looking for research internships in surgery, where I can contribute to clinical and translational projects.

Brief CV

• EducationMD, Facultad de Medicina y Nutrición, Universidad Autónoma de Baja California (UABC), Mexicali
• CurrentResearch placement, Laboratory of Neurophysiology, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Mexico City
• ResearchNeuroscience and epilepsy: bench work on c-Src and Wnt/β-catenin signaling in a rat kindling model with caloric restriction; evidence synthesis, including a systematic review and meta-analysis of surgical outcomes in drug-resistant epilepsy (in progress) and a bibliometric analysis of non-pharmacological epilepsy treatments.
• PublicationsCo-author of a 2026 article in Neuroglia on Huntington’s disease as a neuroglial systems disorder, and contributor to additional neuroscience manuscripts.
• Technical skillsPerioperative care and monitoring in rodent models (ESP32-based monitoring web app in MicroPython); meta-analysis in R (metafor, GRADE); Scopus and VOSviewer; Python.

Open to conversations with surgery programs and research groups: contact@villarobledo.me